🧬PDRN (Salmon DNA)
The foundation of the PDRN Collection
A clinically inspired polynucleotide selected to support hydration and healthier looking skin.
🇦🇺 Australian Owned•🚚 Free Shipping On Orders Over $120 AU Only•🌍 We Ship Worldwide•🎁 Free Gift On Orders Over $100•📦 Same Day Dispatch Before 12pm•🐰 Cruelty Free•🌸 Fragrance Free•🇦🇺 Australian Owned•🚚 Free Shipping On Orders Over $120 AU Only•🌍 We Ship Worldwide•🎁 Free Gift On Orders Over $100•📦 Same Day Dispatch Before 12pm•🐰 Cruelty Free•🌸 Fragrance Free•
20% OffPDRNFree Shipping to Australia
On orders over $120 AUD
US & UAE: estimated delivery 5–10 business days
International shipping calculated at checkout
Pairs well with
PDRN Peptide Serum
$71.20 AUD
PDRN Peptide Cream
A barrier replenishing daily moisturiser developed for lasting hydration and healthier looking skin.
(5 Reviews)via Judge.mePDRN Skincare
More than a moisturiser. The PURESKIN PDRN Peptide Cream combines clinically inspired PDRN Technology, Premium EGF Peptide and a Barrier Recovery Complex to help replenish moisture, strengthen the skin barrier and deliver lasting comfort throughout the day.
$63.20 AUD$79.00 AUD
Free shipping on orders over $120 · Same day dispatch before 12pm
Customers who bought this also bought
- PDRN Peptide Serum+ $71.20 AUD
- PDRN Hydrating Cleanser+ $47.20 AUD
🧬PDRN Technology
💙Premium EGF Peptide
🛡️Barrier First Formula
💧Long-Lasting Hydration
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Three Advanced Skin Technologies
PDRN Technology
Clinically inspired Salmon DNA supporting hydration and healthier looking skin.
Premium EGF Peptide
Oligopeptide-1 helps support smoother, firmer and healthier looking skin.
Barrier Recovery Complex
Ceramide NP, Beta-Glucan and Panthenol reinforce the skin's moisture barrier.
Advanced Hydration
Ectoin and Sodium Hyaluronate provide lasting hydration throughout the day.
Clinical skincare, elevated.
Every PURESKIN formula is purposefully developed around clinically inspired actives, barrier first science and ingredient synergy, because healthier looking skin starts with better formulation.
Clinically inspired FormulasPurposefully FormulatedPerformance Driven Ingredients
🧬Precision Peptides
Advanced peptide technology
A carefully selected blend of biomimetic peptides that support smoother, firmer looking skin.
🛡️Ceramide NP
Barrier Lipid
Helps replenish essential barrier lipids and strengthen the skin's moisture barrier.
🌿Ectoin
Environmental Defence
An advanced extremolyte that helps defend against environmental stress while maintaining hydration.
💧Multi Weight Hyaluronic Acid
Layered Hydration
Multiple molecular weights deliver hydration throughout the skin for immediate and lasting moisture.
🛡️Beta-Glucan
Barrier Support
A soothing polysaccharide that helps reinforce the skin barrier while improving moisture retention.
🌱Centella Asiatica
Botanical Recovery
Rich in calming compounds that help comfort stressed skin and support a healthier looking complexion.
✨Niacinamide
Skin Conditioning
A well studied vitamin B3 derivative that supports an even, refined and healthier looking complexion.
Why This Formula Works
🧬
PDRN Technology
💙
Premium EGF Peptide
🛡️
Barrier Recovery Complex
💧
Advanced Hydration
Clinically inspired.
Every formula is designed to complement the next, creating a complete routine focused on hydration, recovery and barrier support.
Simple. Powerful.
5 Reviews
Verified customersLara Clarke
Verified13/10/2026 · Melbourne, Victoria, Australia
Absolutely love this cream! It has honestly made such a difference to my skin, especially when dealing with dryness and dermatitis. My skin can get quite dry, red and irritated, but since using this cream, I’ve noticed it feels so much more hydrated, calm and nourished. The formula is super gentle and soothing, and it provides long-lasting moisture without feeling too heavy or greasy. It has really helped improve the appearance of my dry patches and made my skin feel softer, smoother and healthier overall. I love how comfortable my skin feels after applying it, especially when it’s feeling sensitive. Definitely a staple in my skincare routine and something I would highly recommend to anyone struggling with dry or sensitive skin!
Layla
Verified12/10/2026 · Melbourne, Victoria, Australia
My skin was so dry before I tried this moisturiser, ever since I started using this my skin improved so much! Life saver ❤️
Olivia
Verified12/10/2026 · Melbourne, Victoria, Australia
Recommended by a friend to try and so far it’s really nice on the skin
Maya
Verified12/10/2026 · Melbourne, Victoria, Australia
This cream is so hydrating but it doesn’t feel thick like others. Really happy with it so far
Jessica
Verified28/10/2026 · Melbourne, Victoria, Australia
Really love this cream! It feels so nice on my skin and keeps it feeling hydrated all day. Its not too thick or greasy either which I love. My skin has been feeling so much softer since using it and a little bit goes a long way.
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Leave a reviewFormula Architecture
More Than A Moisturiser.
A barrier first recovery cream built around PDRN.
The PURESKIN PDRN Peptide Cream is more than a daily moisturiser. It's a clinically inspired barrier recovery treatment designed to deeply hydrate, replenish essential skin lipids and support healthier looking skin. Powered by PDRN (Salmon DNA) and an advanced blend of barrier supporting ingredients, biomimetic peptides and lasting hydrators, every ingredient has been selected to strengthen the skin barrier, improve comfort and support long term skin resilience.
🧬
PDRN
The Hero Technology
At the heart of the formula is PDRN (Salmon DNA), a clinically inspired polynucleotide selected to support skin hydration, visible recovery and a healthier looking complexion.
Hero Ingredient
- •PDRN (Salmon DNA)
🛡️
Barrier
Barrier Recovery Complex
A healthy skin barrier is the foundation of healthy skin. Ceramide NP, Panthenol and Beta-Glucan work together to replenish barrier lipids, reduce moisture loss and improve skin resilience.
Hero Ingredients
- •Ceramide NP
- •Panthenol
- •Beta-Glucan
💙
Peptide Support
Biomimetic Skin Conditioning
Unlike many everyday moisturisers, this formula features Oligopeptide-1 (EGF), a premium biomimetic peptide selected to support smoother, healthier looking skin. Combined with PDRN, it helps create a more advanced skin conditioning system than hydration alone.
Hero Ingredient
- •Oligopeptide-1 (EGF)
🌿
Nourishment
Lasting Comfort
A blend of advanced emollients and skin conditioning ingredients helps lock in hydration while improving softness, comfort and overall skin resilience throughout the day.
Hero Ingredients
- •Ectoin
- •Sodium Hyaluronate
- •Centella Asiatica
- •Allantoin
- •Oat Extract (Avena Sativa)
Why It's Different.
Many moisturisers focus on hydration alone. The PURESKIN PDRN Peptide Cream combines four complementary technologies in one formula: PDRN Technology, a Barrier Recovery Complex, premium Peptide Support and lasting Nourishment. Each technology has been carefully selected to complement the next, creating a moisturiser that supports hydration, barrier function and overall skin health, not just temporary moisture.
🧬PDRN
🛡️Ceramide NP + Beta-Glucan
💙Oligopeptide-1 (EGF)
🌿Ectoin
💧Sodium Hyaluronate
🌱Centella + Allantoin
🌾Panthenol
Why PURESKIN took a different approach. Many barrier creams rely on occlusive ingredients alone to reduce moisture loss. The PDRN Peptide Cream is built around ingredient synergy. PDRN forms the foundation, while Ceramide NP, EGF (Oligopeptide-1), Ectoin and Beta-Glucan work together to strengthen the skin barrier, maintain hydration and support healthier looking skin over time. The result is a moisturiser designed not only to hydrate, but to actively support the skin's natural resilience and recovery.
Three Advanced Technologies. One Daily Moisturiser.
The PURESKIN PDRN Peptide Cream combines clinically inspired PDRN, premium EGF peptide and a barrier recovery complex to deliver more than hydration alone.
🧬 PDRN Technology💙 Premium EGF Peptide🛡️ Barrier Recovery
🧬PDRN Technology
Clinically inspired polynucleotide technology that supports hydration and healthier looking skin.
💙Premium EGF Peptide
Oligopeptide-1 (EGF), a biomimetic peptide selected to support smoother, healthier looking skin.
🛡️Barrier Recovery Complex
Ceramide NP, Beta-Glucan and Panthenol help strengthen the skin barrier and lock in moisture.
💧Advanced Hydration
Ectoin and Sodium Hyaluronate help maintain hydration while protecting against environmental stress.
Free shipping over $120Same day dispatch before 12pmAustralian ownedClinically inspired formulasFree shipping over $120Same day dispatch before 12pmAustralian ownedClinically inspired formulasFree shipping over $120Same day dispatch before 12pmAustralian ownedClinically inspired formulasFree shipping over $120Same day dispatch before 12pmAustralian ownedClinically inspired formulasFree shipping over $120Same day dispatch before 12pmAustralian ownedClinically inspired formulasFree shipping over $120Same day dispatch before 12pmAustralian ownedClinically inspired formulasFree shipping over $120Same day dispatch before 12pmAustralian ownedClinically inspired formulasFree shipping over $120Same day dispatch before 12pmAustralian ownedClinically inspired formulas
PDRN SALMON DNA
More Than A Moisturiser.
Most moisturisers focus on hydration. The PURESKIN PDRN Peptide Cream combines three advanced skin technologies: PDRN Technology, Premium EGF Peptide and a Barrier Recovery Complex, to help improve skin comfort, hydration and resilience while supporting healthier looking skin over time.
🧬
Hero Technology
Clinically inspired Salmon DNA (PDRN) forms the foundation of the formula, supporting skin hydration and promoting a healthier looking complexion.
💙
Premium EGF Peptide
Powered by Oligopeptide-1 (EGF), a biomimetic peptide selected to support smoother, healthier looking skin and elevate the formula beyond a traditional moisturiser.
🛡️
Barrier Recovery Complex
Ceramide NP, Beta-Glucan and Panthenol work together to replenish barrier lipids, reinforce the skin's moisture barrier and improve long term skin comfort.
💧
Advanced Hydration Complex
Ectoin and Sodium Hyaluronate provide lasting hydration while helping defend against environmental stress and maintaining skin softness throughout the day.
Your routine
Your PDRN Recovery Routine
Use morning and night as part of your PDRN ritual. Apply to clean skin and follow with your moisturiser.
☀️Morning
Protect & Hydrate
🌙Evening
Repair & Recover
How it fits together
🫧
Cleanse
Daily
🧬
Serum
Daily
🛡️
Cream
Daily
🩷
Mask
1–2x weekly
The full routine
The Complete PDRN Collection
Four clinically inspired formulas designed to work together as one complete recovery system.
- ✓PDRN Hydrating Cleanser
- ✓PDRN Peptide Serum
- ✓PDRN Peptide Cream
- ✓PDRN Hydrogel Mask (4-Pack)
$209.00 AUD$296.00 AUDSave $87.00 AUD30% Off
🫧 Cleanse
PDRN Hydrating Cleanser
🧬 Treat
PDRN Peptide Serum
🛡️ Moisturise
PDRN Peptide Cream
💧 Mask
PDRN Hydrogel Mask (4-pack)
THE PDRN COLLECTION
Healthy Skin Starts With The Right Foundation.
Discover the complete PURESKIN PDRN Collection. Four clinically inspired formulas developed to cleanse, hydrate, support the skin barrier and promote healthier looking skin.
Shop The PDRN CollectionSecure checkout· Free shipping $120+
Complete the ritual
More from the PDRN range
Free shipping on orders over $120